Sildenafil citrate does not reduce exercise tolerance in men with erectile dysfunction and chronic stable angina
Key result
Sildenafil increased the time to limiting angina by 20 seconds (95% CI, 1-39; P=0.040) compared to placebo in men with erectile dysfunction and chronic stable angina.
Why the study?
Does sildenafil affect exercise tolerance and ischaemic threshold in men with erectile dysfunction and chronic stable angina not taking nitrates?
Population
Men with erectile dysfunction and chronic stable angina (exercise-induced angina) not taking nitrates.
Comparison
Sildenafil 100 mg administered 1 hour prior to… vs Placebo administered 1 hour prior to treadmill…
Design
RCT, double-blind
Follow-up
Acute (during treadmill exercise 1 hour post-dose)
Authors
Discussion
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Implication
Sildenafil appears safe for exercise tolerance in stable angina without nitrates; extends PDE5 inhibitor safety data in comorbid CAD.
Study Design
Type
RCT
Blinding
Double-blind
Structured PICO
Does sildenafil affect exercise tolerance and ischaemic threshold in men with erectile dysfunction and chronic stable angina not taking nitrates?
P
Population
Men with erectile dysfunction and chronic stable angina on antianginal therapy not taking nitrates.
I
Intervention
Sildenafil 100 mg administered 1 hour prior to treadmill exercise, in addition to background antianginal therapy.
C
Comparator
Placebo administered 1 hour prior to treadmill exercise, in addition to background antianginal therapy.
O
Outcome
Time to limiting angina during incremental treadmill exercise.surrogate
Main Result
Mean Difference: 20 (95% CI 1–39)
p-value: p=0.040
Sildenafil is well tolerated and does not adversely affect exercise parameters in men with chronic stable angina not taking nitrates.
Cite This Study
Keith A.A. Fox (2003) conducted an RCT in Erectile dysfunction and chronic stable angina. Sildenafil vs. Placebo was evaluated on Time to limiting angina during incremental treadmill exercise (MD 20s, 95% CI 1-39, p=0.040). Sildenafil increased the time to limiting angina by 20 seconds (95% CI, 1-39; P=0.040) compared to placebo in men with erectile dysfunction and chronic stable angina.