Fluoride Therapy for the Vertebral Crush Fracture Syndrome

Position Papers15 October 1989Fluoride Therapy for the Vertebral Crush Fracture SyndromeA Status ReportRobert P. Heaney, MD, David J. Baylink, MD, C. Conrad Johnston Jr., MD, L. Joseph Melton III, MD, Pierre J. Meunier, MD, Timothy M. Murray, MD, Charles Nagant de Deuxchaisnes, MDRobert P. Heaney, MDSearch for more papers by this author, David J. Baylink, MDSearch for more papers by this author, C. Conrad Johnston Jr., MDSearch for more papers by this author, L. Joseph Melton III, MDSearch for more papers by this author, Pierre J. Meunier, MDSearch for more papers by this author, Timothy M. Murray, MDSearch for more papers by this author, Charles Nagant de Deuxchaisnes, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-8-678 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFluoride has been proposed as a therapy for the vertebral crush fracture syndrome for many years; such proposals have been based largely on the well-characterized syndrome of fluoride intoxication (fluorosis), which is marked by increased skeletal mass and sometimes exuberant bony overgrowths (1-4). For various reasons, including the inability to develop a patentable product, the clinical studies necessary to follow this lead and establish efficacy and safety have proceeded slowly. Nevertheless, much information on fluoride use in the treatment of the vertebral crush fracture syndrome has been amassed, and during the past 9 years fluoride therapy has been approved for...References1. Roholm K. Fluoride Intoxication: A Clinical-Hygienic Study; with a Review of the Literature and Some Experimental Investigations. London, England: H. K. Lewis & Company; 1937. Google Scholar2. SinghJollyBansalMathur ASBC. Endemic fluorosis: epidemiological, clinical and biochemical study of chronic fluorine intoxication in Panjab (India). Medicine. 1963;42:229-46. CrossrefMedlineGoogle Scholar3. RichEnsinckIvanovich CJP. The effects of sodium fluoride on calcium metabolism of subjects with metabolic bone diseases. J Clin Invest. 1964;43:545-56. CrossrefMedlineGoogle Scholar4. EriksenHodgsonRiggs ESB. Treatment of osteoporosis with sodium fluoride. In: Riggs BL, Melton LJ III, eds. Osteoporosis. New York: Raven Press, 1988:415-32. Google Scholar5. J Bone Mineral Res. 1989;4(Suppl 2): [In press]. Google Scholar6. BattistaFletcher RS. Making recommendations on preventive practices: methodological issues. Am J Prev Med. 1988;4:53-76. MedlineGoogle Scholar7. MamelleMeunierDusan NPR. Risk-benefit ratio of sodium fluoride treatment in primary vertebral osteoporosis. Lancet. 1988;2:361-5. CrossrefMedlineGoogle Scholar8. GutteridgePriceNicholson DRG. Fluoride in osteoporotic vertebral fractures-trabecular increase, vertebral fractures, femoral fractures. In: Christiansen C, Arnaud CD, Nordin BE, Parfitt AM, Peck WA, Riggs BL, eds. Osteoporosis 2. Copenhagen, Denmark: Aalborg Stifsbogtrykkeri; 1984:705-7. Google Scholar9. HedlundGallagher LJ. Increased incidence of hip fracture in osteoporotic women treated with sodium fluoride. J Bone Mineral Res. 1989;4:223-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From Creighton University, Omaha, Nebraska; Loma Linda University, Loma Linda, California; Indiana University, Indianapolis, Indiana; Mayo Clinic, Rochester, Minnesota; INSERM-U.234, Faculté Carrel, Lyon, France; University of Toronto, Toronto, Ontario; and Catholic University of Louvain, Brussels, Belgium. For current author addresses, see end of text. 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The randomized controlled trial revisitedFluoride therapy in postmenopausal osteopenic women: Effect on vertebral and femoral bone density and prediction of bone responseToward a cure for osteoporosis: Reversal of excessive bone fragilityFluoride therapy for osteoporosis: A review of dose response, duration of treatment, and skeletal sites of actionCan the adult skeleton recover lost bone?Chapter 21. Recent Advances in Bone Metabolism and Osteoporosis ResearchPhysiological and Pharmacological Regulation of Biological CalcificationEvaluating the impact of municipal water fluoridation on the aquatic environment.Intermittent Cyclical Etidronate Treatment of Postmenopausal OsteoporosisFluoride treatment for osteoporosisFluoride treatment for osteoporosisEffect of Fluoride Treatment on the Fracture Rate in Postmenopausal Women with Osteoporosis“Osteoporosis”: Etiologies, prevention, and treatment 15 October 1989Volume 111, Issue 8Page: 678-680KeywordsArthritisIntoxicationSafetySafety studies Issue Published: 15 October 1989 PDF downloadLoading ...