What question did this study set out to answer?

To summarize recent developments in using inexpensive first-row transition metals to catalyze dehydrogenative C(sp3)–H bond functionalization.

November 11, 2015European Journal of Organic Chemistry

Recent Advances in First‐Row‐Transition‐Metal‐Catalyzed Dehydrogenative Coupling of C(sp3)–H Bonds

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To summarize recent developments in using inexpensive first-row transition metals to catalyze dehydrogenative C(sp3)–H bond functionalization.
Systematic review of recent literature on first-row-transition-metal-catalyzed cross-dehydrogenative coupling reactions.
Classification of reaction strategies into intramolecular cyclization for C–C bond formation and directed site-selective functionalization.
Inexpensive first-row transition metals demonstrate robust catalytic activity for functionalizing unactivated C(sp3)–H bonds under dehydrogenative conditions.
Current methodologies enable concise intramolecular cyclizations and site-selective C–C bond formations, though broad synthetic application remains underdeveloped.

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Implication

Review demonstrates first-row transition-metal catalysis for C(sp3)–H functionalization in organic synthesis, highlighting practical routes to complex molecules.

Cite This Study

Miao et al. (2015) studied this question.

synapsesocial.com/papers/6a994cb460c7aa7f9327400b https://doi.org/10.1002/ejoc.201501186

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Implication

Review demonstrates first-row transition-metal catalysis for C(sp3)–H functionalization in organic synthesis, highlighting practical routes to complex molecules.

Recent Advances in First‐Row‐Transition‐Metal‐Catalyzed Dehydrogenative Coupling of C(sp3)–H Bonds

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Discussion

Implication

Cite This Study

Recent Advances in First‐Row‐Transition‐Metal‐Catalyzed Dehydrogenative Coupling of C(sp3)–H Bonds

Key Points

Discussion

Implication

Cite This Study

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