Key result
Renal AA amyloidosis was associated with significantly higher urinary angiotensinogen-creatinine ratios compared to healthy controls (1.88 vs. 1.25 µg/g; p=0.023).
Case-Control (n=48)
Urinary angiotensinogen levels are elevated in renal AA amyloidosis and correlate positively with the degree of proteinuria, suggesting a role of the local intrarenal renin-angiotensin system.
May indicate intrarenal RAS activation in AA amyloidosis; hypothesis-generating and should not yet change practice.
OBJECTIVE: The aim of this study was to evaluate the relationship of local intrarenal renin angiotensin system (RAS) with proteinuria in patients with renal AA amyloidosis. METHODS: Thirty-two patients with renal AA amyloidosis (19 male, mean age: 45 ± 13 years) and sixteen healthy controls (5 male, mean age: 32 ± 5 years) were included in this study. Spot urine samples were obtained to measure urinary angiotensinogen (AGT) using human AGT-ELISA, urinary creatinine and protein levels. Logarithmic transformations of urinary AGT-creatinine ratio log(UAGT/Ucre) and urinary protein-to-creatinine ratio (UPCR) were done to obtain the normal distributions of these parameters. RESULTS: Log(UAGT/UCre) was significantly higher in patients compared with the controls (1.88 ± 0.92 µg/g vs. 1.25 ± 0.70 µg/g; p = 0.023). Importantly a significantly positive correlation was found between log(UAGT/Ucre) and logUPCR in patients (r = 0.595, p = 0.006). CONCLUSIONS: Urinary AGT levels are higher in renal AA amyloidosis patients than in controls. Also, there is a significant positive correlation between urinary AGT and proteinuria in renal AA amyloidosis.
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Kutlugün et al. (2012) conducted a case-control in Renal AA amyloidosis (n=48). Renal AA amyloidosis vs. Healthy controls was evaluated on Logarithmic transformation of urinary AGT-creatinine ratio log(UAGT/Ucre) (µg/g) (p=0.023). Renal AA amyloidosis was associated with significantly higher urinary angiotensinogen-creatinine ratios compared to healthy controls (1.88 vs. 1.25 µg/g; p=0.023).
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