Key result
Inhaled nitric oxide is a selective pulmonary vasodilator that improves hemodynamics and oxygenation in adult perioperative patients, potentially reducing the need for right ventricular assist device placement.
Why the study?
Does inhaled nitric oxide improve hemodynamics and prevent right ventricular failure in adults undergoing perioperative cardiothoracic procedures?
Does inhaled nitric oxide improve hemodynamics and prevent right ventricular failure in adults undergoing perioperative cardiothoracic procedures?
Inhaled nitric oxide is a safe, selective pulmonary vasodilator that improves perioperative hemodynamics and may avert the need for right ventricular assist device placement in adult cardiothoracic surgery patients.
iNO may be considered perioperatively; leaves open RVAD benefit pending RCTs.
Pulmonary arterial hypertension and hypoxemia constitute a significant cause of postoperative right heart failure and mortality. Timely administration of inhaled nitric oxide (iNO) can improve hemodynamic parameters and oxygenation in patients undergoing heart and/or lung transplantation and various high-risk cardiac procedures involving coronary artery bypass grafting and/or left ventricular assist device placement. As a diagnostic tool, iNO can be used to identify heart transplant recipients at high risk of right ventricular failure and patients with primary pulmonary hypertension who may benefit from vasodilator therapy. In addition to its role as a potent and selective pulmonary vasodilator, iNO is a useful intraoperative adjunct in adult cardiac surgery patients that may reduce the need for right ventricular assist device placement. This review focuses on the multiple clinical applications of iNO in perioperative patient care.
No takes yet. Share an insight, caveat, or question.
Öz et al. (2004) conducted a review in Pulmonary arterial hypertension and right ventricular failure in perioperative settings. Inhaled nitric oxide (iNO) vs. Intravenous vasodilators or other inhaled agents (e.g., iloprost) was evaluated. Inhaled nitric oxide is a selective pulmonary vasodilator that improves hemodynamics and oxygenation in adult perioperative patients, potentially reducing the need for right ventricular assist device placement.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: