Key result
Venous blood gas analysis showed excellent agreement with arterial analysis for pH (R = 0.69) and acceptably good agreement for PCO2 (R = 0.93) and HCO3 (R = 0.82) in patients with DKA.
Why the study?
ABGA is standard in DKA but painful and prone to complications, and whether minimally invasive VBGA can replace it remains controversial.
Does venous blood gas analysis correlate with arterial blood gas analysis in the evaluation of patients presenting with diabetic ketoacidosis?
Observational (n=76)
Does venous blood gas analysis correlate with arterial blood gas analysis in the evaluation of patients presenting with diabetic ketoacidosis?
Effect estimate: R = 0.69 (pH), R = 0.93 (PCO2), R = 0.82 (HCO3)
Venous blood gas analysis shows good correlation with arterial blood gas analysis for pH, PCO2, and HCO3, suggesting it can be a safer, minimally invasive alternative for initial evaluation of DKA.
Venous blood gas may substitute for arterial sampling in initial DKA evaluation; supports correlation but leaves practice change open pending prospective validation.
Background Diabetic ketoacidosis (DKA) is one of the most severe complications of diabetes mellitus (DM). Arterial blood gas analysis (ABGA) has been used as a conclusive diagnostic test for DKA. However, ABGA sampling is technically challenging, painful and may cause multiple complications. Venous blood gas analysis (VBGA) is a minimally invasive alternative for ABGA; however, the correlation between ABGA and VBGA has been controversial. Thus, the correlation between arterial and venous pH, partial pressure of CO2 (PCO2), and bicarbonate (HCO3) was studied. Objective To determine whether VBGA can replace ABGA in the evaluation of patients presenting with DKA. Material and Methods The present observational study was carried out in 76 patients with DKA. Two samples for ABGA and VBGA were obtained from each patient as close to each other as possible and were immediately sent to the laboratory. Data analysis was done using Pearson’s correlation coefficient (R) and Bland and Altman plots. Results The Bland and Altman plots and Pearson’s correlation coefficient depicted excellent agreement between arterial and venous pH (R = 0.69) and acceptably good agreement between arterial and venous PCO2 (R = 0.93) and HCO3 (R = 0.82). Conclusion Thus, VBGA can be used in the initial diagnosis and evaluation of DKA, allowing the utilisation of a minimally invasive, safer option to ABGA.
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Sandeep Kumar Immadisetty (2022) conducted an observational in Diabetic ketoacidosis (DKA) (n=76). Venous blood gas analysis (VBGA) vs. Arterial blood gas analysis (ABGA) was evaluated on Correlation between arterial and venous pH, partial pressure of CO2 (PCO2), and bicarbonate (HCO3) (R = 0.69 (pH), R = 0.93 (PCO2), R = 0.82 (HCO3)). Venous blood gas analysis showed excellent agreement with arterial analysis for pH (R = 0.69) and acceptably good agreement for PCO2 (R = 0.93) and HCO3 (R = 0.82) in patients with DKA.
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