Key result
Surgical resection in soft tissue sarcoma patients aged ≥75 years yielded a 5-year overall survival of 51.8%, and metastasectomy improved median survival after metastasis (18.2 vs 3.2 months).
Why the study?
This study aimed to analyze the treatment decision-making process and clinical outcomes in patients with soft tissue sarcoma aged 75 years and older.
Does surgical resection improve survival in patients with soft tissue sarcoma aged 75 years and older?
Observational (n=72)
Does surgical resection improve survival in patients with soft tissue sarcoma aged 75 years and older?
Surgical resection and metastasis treatment may improve survival in elderly patients with soft tissue sarcoma who have adequate physical condition.
May inform age-stratified surgical decisions in elderly STS; leaves open need for prospective validation of outcomes.
BACKGROUND/AIM: This study aimed to analyze the decision-making process of treatment and the clinical outcomes of patients with STS aged 75 years and older. PATIENTS AND METHODS: Overall, 72 patients were reviewed. The mean and median ages were 82 and 81 years, respectively. RESULTS: Of the 72 patients, 17 did not undergo surgical resection. Age was related to the decision to pursue surgical treatment. Resection was performed in 55 patients. The 5-year overall survival was 51.8%. Patients with an American Society of Anesthesiologists physical status (ASA-PS) score of 3 had a worse survival. Twenty-five patients developed metastasis. The median survival time after metastasis in 12 patients who received metastasectomy and/or lung radiofrequency ablation was superior (18.2 months) to that of the remaining 13 patients without any treatment (3.2 months). CONCLUSION: Surgical treatment should be considered in elderly patients if their physical condition is not poor. ASA-PS score may be a tool to indicate physical condition.
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Nakamura et al. (2018) conducted an observational in Soft Tissue Sarcoma (n=72). Surgical resection vs. No surgical resection was evaluated on 5-year overall survival. Surgical resection in soft tissue sarcoma patients aged ≥75 years yielded a 5-year overall survival of 51.8%, and metastasectomy improved median survival after metastasis (18.2 vs 3.2 months).
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