Key result
Persistently infected carrier sows shedding Senecavirus A in secretions or feces successfully transmitted the virus to contact piglets, indicating they can serve as reservoirs for infection.
Why the study?
Persistent viral infections have significant implications for disease control strategies, and previous studies demonstrated SVA RNA persistence long after clinical disease resolution.
Answers are grounded in this paper and cite their sources.
May necessitate enhanced SVA surveillance in swine; leaves open transmission risks and control strategies.
Persistent viral infections have significant implications for disease control strategies. Previous studies demonstrated the persistence of SVA RNA in the tonsil of experimentally or naturally infected animals long after resolution of the clinical disease. Here, we showed that SVA establishes persistent infection in SVA-infected animals, with the tonsil serving as one of the sites of virus persistence. Importantly, persistently infected carrier animals shedding SVA in oral and nasal secretions or feces can serve as sources of infection to other susceptible animals, as evidenced by successful transmission of SVA from persistently infected sows to contact piglets. These findings unveil an important aspect of SVA infection biology, suggesting that persistently infected pigs may function as reservoirs for SVA.
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Maggioli et al. (2019) studied Senecavirus A (SVA) infection. Senecavirus A (SVA) infection was evaluated on Persistent infection and transmission. Persistently infected carrier sows shedding Senecavirus A in secretions or feces successfully transmitted the virus to contact piglets, indicating they can serve as reservoirs for infection.
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