The Efficient One‐Pot Reaction of up to Eight Components by the Union of Multicomponent Reactions

E=MCR2! The introduction of orthogonal functional groups in multicomponent reactions (MCRs) with unique solvent and functional-group compatibility enables their combination with other multicomponent reactions in one pot. The resulting novel 5- and 6CRs and an unprecedented 8CR afford very complex products in up to 80 % yields (see picture), with up to nine new bond formations and eleven diversity points in a single reaction.