Key result
Infection with the FAdV-4 GX-1 strain caused 100% mortality in 10-day-old specific pathogen-free chickens at a dose of 10^4 TCID50 within 3 days post-infection.
Why the study?
Hydropericardium-hepatitis syndrome causes huge economic losses in the Chinese poultry industry, prompting isolation and characterization of causative fowl adenovirus strains.
The FAdV-4 GX-1 strain is a highly virulent causative agent of hydropericardium-hepatitis syndrome in chickens, causing significant mortality and cardiac/hepatic pathology.
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GX-1 FAdV-4 causes 100% mortality in chickens; leaves open targeted vaccine and control strategies for HHS outbreaks.
Ren et al. (2019) studied Hydropericardium-hepatitis syndrome (HHS). FAdV-4 GX-1 strain was evaluated on Mortality. Infection with the FAdV-4 GX-1 strain caused 100% mortality in 10-day-old specific pathogen-free chickens at a dose of 10^4 TCID50 within 3 days post-infection.