Key result
Fowl adenovirus type 1 (FAV JM1/1) multiplied efficiently in homologous chicken kidney cells but underwent abortive infection in heterologous CRFK and Vero cells due to suppressed viral gene expression.
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Fowl adenovirus type 1 undergoes abortive infection in heterologous mammalian cells due to suppression of viral gene expression after adsorption.
The JM1/1 strain of fowl adenovirus (FAV) serotype 1 isolated from gizzard erosion was used to investigate the biology of FAV in homologous (susceptible) and heterologous cells. The FAV JM1/1 strain is capable of efficient multiplication in primary chicken kidney (CK) cells, but not in Crandell-Rees feline kidney (CRFK) cells or Vero cells. FAV adsorption in heterologous cells was slightly higher than in CK cells. An early gene encoding a DNA-binding protein and a late gene encoding the hexon protein were expressed in CK cells. Only the early gene was expressed in Vero cells. Neither of these genes was expressed in CRFK cells. These results suggest that the virus was unable to multiply effectively due to suppression of viral gene expression in the heterologous cells used in this study.
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Taharaguchi et al. (2012) studied this question. Fowl adenovirus type 1 (FAV JM1/1 strain) infection vs. Homologous cells (CK cells) vs Heterologous cells (CRFK and Vero cells) was evaluated on Viral multiplication and gene expression. Fowl adenovirus type 1 (FAV JM1/1) multiplied efficiently in homologous chicken kidney cells but underwent abortive infection in heterologous CRFK and Vero cells due to suppressed viral gene expression.
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