Key result
Elevated airway surface liquid glucose concentrations in patients with diabetes mellitus promote the growth of respiratory pathogens and increase the risk of severe pulmonary infections.
Highlights the association between diabetes mellitus and increased risk of severe pulmonary infections, noting a gap in knowledge regarding respiratory cell defense mechanisms in these patients.
Answers are grounded in this paper and cite their sources.
Heightens clinical awareness of severe pulmonary infections in diabetes; leaves open the role of respiratory cell defenses for targeted research.
Type II diabetes mellitus affects all age group and may underestimated in clinical practice. Approximately, 38 % of adults admitted acutely to the general hospital wards are identified to have hyperglycemia. Various associated adverse outcomes in hyperglycemic patients include severe hospital-acquired pneumonia, severe pulmonary infections with antimicrobial resistance, particularly Staphylococcus aureusand Pseudomonas aeruginosa, acute myocardial infarction, trauma, diabetic nephropathy, and diabetic retinopathy. Airway-surface-liquid glucose concentration play a major role in protecting the lungs against microbial infections. Currently, there is limitation regarding the knowledge about the interaction of human respiratory cell defense with respiratory pathogens in diabetic patients.
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Attapon Cheepsattayakorn (2017) conducted a review in Diabetes Mellitus and Pulmonary Infectious Diseases. Hyperglycemia vs. Normoglycemia was evaluated. Elevated airway surface liquid glucose concentrations in patients with diabetes mellitus promote the growth of respiratory pathogens and increase the risk of severe pulmonary infections.
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