The action of cystine and methionine on liver fat deposition

BEESTON & CHANNON [1936] reported early studies on the question as to whether the preventive action of proteins, such as caseinogen, on fat deposition in the liver was to be attributed to one or more of the constituent amino-acids.Investigation of the action of cystine showed that, so far from preventing fat deposition, this particular amino-acid accelerated it in a remarkable manner.Thus the mean percentage of fat in the livers of 45 control animals receiving a diet containing 40 % fat and 5 % caseinogen was increased from 2195 to 31-78