Key result
The isolated perfused rat lung releases a low molecular mass peptide form of immunoreactive atrial natriuretic factor that inhibits forskolin-stimulated aldosterone secretion.
Population
Isolated perfused rat lung model and rat zona glomerulosa cell suspensions
Comparison
Lung perfusion and evaluation of released atrial… vs Synthetic C-terminal part of the prohormone
Design
Preclinical
Authors
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Does not yet inform practice; extends ANF secretion to rat lung and leaves open human aldosterone effects.
The study demonstrates that the rat lung secretes a biologically active, low molecular mass form of atrial natriuretic factor capable of inhibiting aldosterone secretion.
Gutkowska et al. (1987) studied this question. Lung perfusion was evaluated on Secretion of ANF and its biological effect. The isolated perfused rat lung releases a low molecular mass peptide form of immunoreactive atrial natriuretic factor that inhibits forskolin-stimulated aldosterone secretion.
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