Why the study?
Rate-dependent LBBB during exercise testing is traditionally considered a potential marker of CAD, but its long-term prognosis remains uncertain.
Population
68 patients with rate-dependent LBBB during exercise testing
Design
Retrospective single-centre cohort study
Follow-up
Median 12.8 years
Key result
Rate-dependent LBBB during exercise testing progressed to permanent LBBB in 52.9% of patients over a median follow-up of 12.8 years.
Authors
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Exercise-induced LBBB may warrant closer surveillance for progression; leaves open whether early intervention alters outcomes in this observational cohort.
Cohort (n=68)
No
Rate-dependent LBBB during exercise testing frequently progresses to permanent LBBB and is associated with subsequent systolic dysfunction, suggesting it is an early manifestation of intrinsic conduction system disease.
Droogne et al. (2026) conducted a cohort in Rate-dependent left bundle branch block (LBBB) (n=68). Rate-dependent left bundle branch block (LBBB) was evaluated on progression to permanent LBBB. Rate-dependent LBBB during exercise testing progressed to permanent LBBB in 52.9% of patients over a median follow-up of 12.8 years.
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