Alpha-Interferon for Severe Cold Agglutinin Disease

Brief Reports1 August 1989Alpha-Interferon for Severe Cold Agglutinin DiseaseBrian M. O'Connor, MD, Jacqueline S. Clifford, BS, William D. Lawrence, MD, Gerald L. Logue, MDBrian M. O'Connor, MD, Jacqueline S. Clifford, BS, William D. Lawrence, MD, Gerald L. Logue, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-3-255 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCold agglutinin disease may be classified as primary or secondary. Monoclonal IgM (occasionally IgG or IgA) proteins with the ability to bind to erythrocytes below body core temperature are found in the sera of patients with the primary (idiopathic) and secondary forms associated with lymphoproliferative disorders (1). In these disorders mild to moderate hemolytic anemia results from the deposition of complement as the cold agglutinin binds to the erythrocyte in the acral circulation. On exposure to cold, episodes of hemoglobinuria related to marked intravascular hemolysis may occur. Exposure to cold may also produce painful acrocyanosis caused by sludging and deoxygenation...References1. CrispPruznaski DW. B-cell neoplasms with homogeneous cold-reacting antibodies (cold agglutinins). Am J Med. 1982;72:915-22. CrossrefMedlineGoogle Scholar2. HippeJensenOlesenLindThomsen EKHKP. Chlorambucil treatment of patients with cold agglutinin syndrome. Blood. 1970;35:68-72. CrossrefMedlineGoogle Scholar3. DacieWorlledge JS. Autoimmune hemolytic anemias. In: Brown EB, Moore CV, eds. Progress in Hematology. v 6. New York: Grune and Stratton; 1969:82-120. Google Scholar4. Schubothe H. The cold hemagglutinin disease. Semin Hematol. 1966;3:27-47. MedlineGoogle Scholar5. TaftProppSullivan ERS. Plasma exchange for cold agglutinin hemolytic anemia. Transfusion. 1977;17:173-6. CrossrefMedlineGoogle Scholar6. SilbersteinRobertsonHarrisMoreauBesaNowell LGALEP. Etiologic aspects of cold agglutinin disease: evidence for cytogenetically defined clones of lymphoid cells and the demonstration that an anti-Pr cold autoantibody is derived from a chromosomally aberrant B cell clone. Blood. 1986;67:1705-9. CrossrefMedlineGoogle Scholar7. QuesadaGuttermanHersh JJE. Treatment of hairy cell leukemia with alpha interferons. Cancer. 1986;57:1678-80. CrossrefMedlineGoogle Scholar8. QuesadaAlexanianHawkins JRM. Treatment of multiple myeloma with recombinant alpha-interferon. Blood. 1986;67:275-8. CrossrefMedlineGoogle Scholar9. BonomoCasatoAfeltraCaccavo LMAD. Treatment of idiopathic mixed cryoglobulinemia with alpha interferon. Am J Med. 1987;83:726-30. CrossrefMedlineGoogle Scholar10. GoldsteinLaszlo DJ. Interferon therapy of cancer: from imaginon to interferon. Cancer Res. 1986;46:4315-29. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Brian M. O'Connor, MD; Jacqueline S. Clifford, BS; William D. Lawrence, MD; Gerald L. Logue, MDAffiliations: From the Buffalo Veterans Administration Medical Center and the State University of New York at Buffalo, Buffalo, New York. For current author addresses, see end of text. 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