Key result
The rs1800497 ANKK1 polymorphism was significantly associated with higher eating behavior scores (OR 1.13), which in turn correlated with total weight loss after bariatric surgery.
Why the study?
Certain polymorphisms are considered markers for addictive disorders and hedonic hunger and are associated with BMI, but their association with bariatric surgery success along with behavioral factors needed evaluation.
Are rs1800497 ANKK1 and rs1799732 DRD2 genetic polymorphisms, eating behavior, hedonic hunger, and depressive symptoms associated with the success of bariatric surgery?
Observational (n=101)
No
Are rs1800497 ANKK1 and rs1799732 DRD2 genetic polymorphisms, eating behavior, hedonic hunger, and depressive symptoms associated with the success of bariatric surgery?
Odds Ratio: 1.13 (95% CI 1.02–1.25)
p-value: p=0.009
The ANKK1 Taq1A polymorphism is associated with eating behavior in patients undergoing bariatric surgery, suggesting that genetic factors may influence post-surgical weight loss outcomes.
Polymorphisms tied to hedonic hunger may affect bariatric outcomes; hypothesis-generating and requires prospective validation.
Introduction: Obesity is considered a risk factor for other chronic illnesses, such as type 2 diabetes mellitus, hypertension, dyslipidemia, cardiovascular diseases, and other disorders. A therapeutic approach is bariatric surgery (BS), which is considered the most effective intervention for severe obesity and ameliorates these comorbidities. Some polymorphisms are considered markers for addictive disorders and hedonic hunger and are associated with BMI. The objective was to analyze factors associated with the success of BS, including rs1800497 ANKK1 and rs1799732 DRD2 polymorphisms, eating behavior, hedonic hunger, and depressive symptoms. Methods We included 101 patients who underwent BS from 2010 to 2021 from the surgery service of a public hospital. We registered anthropometry and applied 3 questionnaires to evaluate eating behavior (TFEQ-R18), hedonic hunger (PFS), and depressive symptoms (PHQ-9). We typed the ANKK1 rs1800497 and rs1799732 DRD2 polymorphisms and evaluated biochemistry characteristics. Results The median weight loss was 34.7 kg with a BMI of 33.8 kg/m2. Weight loss was negatively associated with triglycerides (p = 0.011) and positively associated with the TFEQ-R18 (p = 0.006). Regarding polymorphisms, rs1800497 ANKK1 was associated with TFEQ-R18 (OR = 1.13 (1.02–1.25), p = 0.009), but rs1799732 DRD2 was not associated with either studied variable. We also found a negative correlation of actual BMI with scholarship (r=-0.29, p = 0.02). Conclusion We observed an improvement in metabolic and anthropometric parameters post-BS. Interestingly, the ANKK1 Taq1A polymorphism was associated with eating behavior, and scholarship with BMI could consider predictors of BS outcomes.
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Daza-Hernandez et al. (2022) conducted an observational in Severe obesity (n=101). rs1800497 ANKK1 polymorphism vs. Non-carriers was evaluated on Association with TFEQ-R18 eating behavior score (OR 1.13, 95% CI 1.02-1.25, p=0.009). The rs1800497 ANKK1 polymorphism was significantly associated with higher eating behavior scores (OR 1.13), which in turn correlated with total weight loss after bariatric surgery.
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