Key result
Stress-induced disturbances of contractile function in nonischemic heart divisions after myocardial infarction in rats were prevented by propranolol and membrane-stabilizing factors.
Why the study?
Do membrane-stabilizing factors or propranolol prevent stress-induced contractile dysfunction in nonischemic heart divisions following myocardial infarction in rats?
Population
Rats subjected to myocardial infarction of the left ventricle (isolated right auricle studied)
Comparison
Propranolol, antioxidant ionol, nicotinamide, or… vs Untreated myocardial infarction or…
Design
Preclinical
Follow-up
1 day
Authors
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Rat model suggests propranolol protection against post-MI stress; leaves open human relevance and should not change practice.
Do membrane-stabilizing factors or propranolol prevent stress-induced contractile dysfunction in nonischemic heart divisions following myocardial infarction in rats?
Stress-induced contractile dysfunction in nonischemic regions of the heart post-myocardial infarction can be prevented by beta-blockers and membrane-stabilizing agents in a rat model.
Ф. З. Меерсон (1983) studied myocardial infarction. propranolol, antioxidant ionol, nicotinamide, and chloroquine was evaluated on contractile function of the right auricle. Stress-induced disturbances of contractile function in nonischemic heart divisions after myocardial infarction in rats were prevented by propranolol and membrane-stabilizing factors.
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