Key result
Administration of 500 mL 6% hetastarch minimized hemodynamic responses during spinal anesthesia compared to lactated Ringer's solution, with a smaller decrease in blood pressure (-7% vs -14%, P<.05).
Why the study?
Does 6% hetastarch compared to lactated Ringer's solution improve hemodynamic stability during spinal anesthesia in elderly patients undergoing emergent hip surgery?
Population
24 ASA physical status III elderly patients undergoing emergent hip surgery
Comparison
500 mL 6% hetastarch administered prior to… vs 1500 mL lactated Ringer's solution administered…
Design
RCT, randomized, double-blinded
Follow-up
30 minutes following spinal anesthesia
Authors
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Supports hetastarch preload over crystalloid in spinal anesthesia for elderly hip surgery; extends RCT evidence for volume choice in this population.
RCT (n=24)
Double-blind
Does 6% hetastarch compared to lactated Ringer's solution improve hemodynamic stability during spinal anesthesia in elderly patients undergoing emergent hip surgery?
Absolute Event Rate: -7% vs -14%
p-value: p=<.05
Administration of 6% hetastarch minimizes hemodynamic impairment compared to lactated Ringer's solution during spinal anesthesia in elderly patients undergoing emergent hip surgery.
Marhofer et al. (1999) conducted an RCT in Emergent hip surgery (n=24). 6% hetastarch vs. 1500 mL lactated Ringer's solution was evaluated on Relative change in blood pressure at 30 minutes following spinal anesthesia (p=<.05). Administration of 500 mL 6% hetastarch minimized hemodynamic responses during spinal anesthesia compared to lactated Ringer's solution, with a smaller decrease in blood pressure (-7% vs -14%, P<.05).
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