The expression of murine C-type viral protein p30 is under host genetic control by multiple loci involved in T-cell differentiation and leukemogenesis.
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Loci tied to T-cell differentiation modulate viral protein in mice; leaves open human leukemogenesis relevance.
Congenic strains on A, C57BL/6, and 129 background, which differ from the original strains for specific loci detected, are highly suitable for evaluation of the host genetic control of the expression of C-type viral protein, p30. Significant differences in the p30 concentration in the present study in some of the organs, blood, heart, kidney, lung, spleen and thymus have been demonstrated related to the loci, 77a, Thy-1, Cv-1, Gv-2, Ly-1, and Ly-3, whereas the loci, H-2, and Ly-2 evoked no effect on p30 expression. It is of particular interest that (1) the change of the genotype for two independent loci, Tla, and Thy-1 in the original A strain led to the same differences in the p30 concentration, (2) only Ly-1, and Ly-3 in the Ly-system affected the p30 expression, and (3) significant difference of the H-2 could be demonstrated for blood and thymus. Investigations of the nude locus in BALB/c, C3H, C57BL/6, and NZB congenic strains and the hairless locus in HRS strain disclosed an elevated p30 concentration compared to the coated animals, if the parental strain previously expressed a low p30 concentration. The genes investigated have the following traits: (1) presence/absence of thymus, (2) they determine cell surface antigens on thymocytes and participate in the T-cell differentiation, and (3) they all play a role in leukemogenesis.
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H.-H. KROG (2009) studied this question.
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