Key result
Mammalian type C virus p30-related antigen is linked specifically to lupus glomerulonephritis.
Why the study?
The presence and specificity of type C RNA virus antigens in renal glomeruli and spleen tissue of human SLE patients with lupus proliferative glomerulonephritis were not well characterized.
Observational
Suggests possible type C virus role in proliferative lupus nephritis; hypothesis-generating and should not change practice.
An antigen recognized by antisera produced against p30 (core) proteins of the four chief groups of mammalian type C viruses (murine, feline, RD-114 related to endogenous primate, and infectious primate group) is located in an immune-complex pattern in some renal glomeruli of human SLE patients with lupus proliferative glomerulonephritis but is not detected in normal or pathological control human kidneys. This antigen cross-reacts with p30 interspecies determinants shared by the four chief virus groups and cross-reacts with a partially purified antigen extracted from human SLE spleen. The human SLE spleen antigen cross-reacts with p30 group antigen of RD-114 virus but not of feline or murine viruses. Some host immunoglobulins eluted from a human SLE kidney by acid-buffer show antibody-like activity against p30 group antigen of RD-114 virus but not of simian, feline, or murine viruses.
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Mellors et al. (1978) conducted an observational in Systemic lupus erythematosus (SLE) with lupus proliferative glomerulonephritis. Type C RNA virus p30 antigen expression vs. Normal or pathological control human kidneys was evaluated on Presence of p30 antigen in renal glomeruli. An antigen related to the p30 core protein of mammalian type C viruses was detected in the renal glomeruli of human SLE patients with proliferative glomerulonephritis, but not in control kidneys.
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