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January 1, 1973Intervirology

Multiple Distinct Antigenic Determinants Associated with Murine Type-C Virus Group-Specific Antigen

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Key result

Three serologically active fragments with species-specific and interspecific determinants were identified in tryptic digests of iodinated MuLV major group-specific antigen (p30).

Population

Murine type-C virus major group-specific antigen (p30)

Design

Preclinical

Authors

JDJames DavisThe Ohio State University Wexner Medical CenterHCHoward P. CharmanNational Cancer InstituteSOStephen OroszlanNational Cancer Institute

Discussion

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Implication

May refine retroviral immunoassay sensitivity in research; leaves open translation beyond murine models.

Structured PICO

P
Population
Murine type-C virus major group-specific antigen (p30)
E
Exposure
Tryptic digestion and radioimmunoassay
O
Outcome
Identification of serologically active fragments and antigenic determinantssurrogate

The study identifies multiple distinct antigenic determinants on fragments of the murine type-C virus p30 antigen, enhancing the sensitivity of radioimmunoassays.

Cite This Study

Davis et al. (1973) studied Murine Type-C Virus. Tryptic digests of iodinated MuLV major group-specific antigen (p30) was evaluated on Identification of serologically active fragments and antigenic determinants. Three serologically active fragments with species-specific and interspecific determinants were identified in tryptic digests of iodinated MuLV major group-specific antigen (p30).

synapsesocial.com/papers/6a97c202c5cc395bb1e17241https://doi.org/10.1159/000149440
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Murine Type-C Virus Group-Specific Antigens: Interstrain Immunochemical, Biophysical, and Amino Acid Sequence Differences1974 · 59 citations
  2. 2Chromatographic Separation and Antigenic Analysis of Proteins of the Oncornaviruses IV. Biochemical Typing of Murine Viral Proteins1975 · 30 citations
  3. 3Type-C RNA Virus Gene Expression in Human Tissue1974 · 123 citations
  4. 4Chromatographic separation and antigenic analysis of proteins of the oncornaviruses. V. Identification of a new murine viral protein, p15(E)1975 · 110 citations
  5. 5Radioimmunoassay of Mammalian Type C Viral Proteins1972 · 71 citations