Pathogenesis of Congestive Heart Failure

Article1 September 1961Pathogenesis of Congestive Heart FailureEffect of Posture and Exercise on Plasma Volume and Plasma ConstituentsLLOYD T. ISERI, M.D., F.A.C.P., ETELE L. BALATONY, M.D., JOHN R. EVANS, M.D., MILTON G. CRANE, M.D.LLOYD T. ISERI, M.D., F.A.C.P., ETELE L. BALATONY, M.D., JOHN R. EVANS, M.D., MILTON G. CRANE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-3-384 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe exact mechanism of sodium and water retention in congestive heart failure remains obscure despite the fact that hemodynamic, circulatory, renal, and endocrine factors have been studied extensively. Metabolic studies (1-7) have suggested that certain changes occur in the tissue cells which might be responsible for the ultimate accumulation of salt and water. Electrolyte studies of the plasma in heart failure (8, 9) have concurred indirectly with the hypothesis that circulatory insufficiency produces increased cellular osmolality. In view of these changes, further study of the effect of circulatory stress on the extracellular compartment seemed to be indicated.The effect of...References1. ISERIBOYLEMYERS LTAJGB: Water and electrolyte balance during recovery from severe congestive failure on a 50 milligram sodium diet. Amer. Heart J. 40: 706, 1950. CrossrefMedlineGoogle Scholar2. SQUIRESCROSLEYELKINTON RDAPJR: The distribution of body fluids in congestive heart failure. III. Exchanges in patients during diuresis. Circulation 4: 868, 1951. CrossrefMedlineGoogle Scholar3. MILLER GE: Water and electrolyte metabolism in congestive heart failure. Circulation 4: 270, 1951. CrossrefMedlineGoogle Scholar4. 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Author, Article, and Disclosure InformationAffiliations: Downey, CaliforniaReceived for publication February 10, 1961.From the Rancho Los Amigos Hospital Poliomyelitis Clinical Study Center, Downey, Calif., and the Department of Internal Medicine, College of Medical Evangelists, Los Angeles, Calif.Supported by grants from the American Heart Association and the National Institutes of Health (H-3987). The Poliomyelitis Clinical Study Center is aided by a grant from the National Foundation.Requests for reprints should be addressed to Lloyd T. Iseri, M.D., Chief, Cardiovascular Research, Rancho Los Amigos Hospital, 7601 E. Imperial Highway, Downey, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChanges in fibrinolytic activity in diving grey sealsPathogenesis and management of congestive heart failure—revisitedIncreases in plasma oncotic pressure during acute cardiogenic pulmonary edema.The effect of exercise on haematocrit, plasma volume and viscosity in diabetes mellitusREFERENCESMetabolic and hemodynamic responses to exercise during atrial fibrillation and sinus rhythmNasal airway response to exerciseTHE EFFECT OF SHORT-TERM EXERCISE ON PLASMA VOLUME AND BLOOD PRESSURE IN GUANETHIDINE-TREATED HYPERTENSIVESHematocrit, plasma protein, plasma volume, and viscosity in early hypertensive diseaseEffect of concentrated contrast media during angiography on plasma volume and plasma osmolalityPathogenesis of Congestive Heart Failure Correlation Between Anaerobic Metabolism and Plasma Volume Changes Following ExerciseLLOYD T. ISERI, M.D., F.A.C.P., JOHN R. EVANS, M.D., MICHAEL EVANS, B.A. 1 September 1961Volume 55, Issue 3Page: 384-394KeywordsAttentionBlood plasmaHeart failureHospital medicineLongitudinal studiesPathogenesisPoliomyelitisRenal circulationSaltsSodium Issue Published: 1 September 1961 PDF downloadLoading ...