What question did this study set out to answer?

To document and compare the life span and postmortem pathology across multiple inbred and outbred strains of mice and rats maintained under specified-pathogen-free conditions.

October 1, 1971Laboratory Animals

Life span of specified-pathogen-free (MRC category 4) mice and rats

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Authors

MFMichael F. W. FestingMedical Research Council DBD.K. BlackmoreNational Institutes of Health

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Implication

Observational study reveals substantial lifespan variation and high neoplasia rates in specified-pathogen-free rodents, highlighting strain-specific aging trajectories.

Key Points

To document and compare the life span and postmortem pathology across multiple inbred and outbred strains of mice and rats maintained under specified-pathogen-free conditions.
Tracked 15 inbred and 2 outbred strains of mice, alongside 1 inbred and 1 outbred strain of rats.
Maintained all animals under specified-pathogen-free (MRC category 4) conditions to construct strain-specific survival curves and evaluate pathological findings.
Longevity among mouse strains ranged widely from 312 to 802 days.
Neoplasia represented the most frequent pathological finding across the examined rodent cohorts.

Cite This Study

Festing et al. (1971) studied this question.

synapsesocial.com/papers/6a998e1884d6bd52b628ee07 https://doi.org/10.1258/002367771781006564

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Implication

Observational study reveals substantial lifespan variation and high neoplasia rates in specified-pathogen-free rodents, highlighting strain-specific aging trajectories.

Life span of specified-pathogen-free (MRC category 4) mice and rats

Discussion

Member takes

Implication

Key Points

Cite This Study

Life span of specified-pathogen-free (MRC category 4) mice and rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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