Saccharomyces cerevisiae Bzz1p Is Implicated with Type I Myosins in Actin Patch Polarization and Is Able To Recruit Actin-Polymerizing Machinery In Vitro

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Structured PICO

Population

Saccharomyces cerevisiae (yeast) strains (e.g., FY1679, Y190, Y187, CG1945)

Intervention

Genetic manipulation of BZZ1 (deletion, overexpression, tagging) and type I myosins (MYO3, MYO5)

Comparator

Wild-type yeast strains or single mutants

Outcome

Protein-protein interactions (Bzz1p with Las17p, type I myosins) and actin patch polarizationsurrogate

Bzz1p is a novel SH3 domain protein in yeast that interacts with Las17p and type I myosins to regulate actin polymerization.

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Defines Bzz1p's role in yeast actin dynamics; leaves open relevance to mammalian cardiac cytoskeletal regulation.

Soulard et al. (2002) studied this question.

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