What is the clinical evidence from this study?

Population: Mitral valve replacement. Intervention: Sodium hydroxyethylene diphosphonate vs. Untreated calves. Primary outcome: Platelet deposition and calcium content on the valves.

What does this research mean for the field?

Sodium hydroxyethylene diphosphonate reduces platelet deposition but does not reduce calcium content on bovine pericardial valves at 30 days post-implantation compared with untreated controls. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 3, 2026European Heart Journal

Platelet deposition on and calcification of bovine pericardial valve

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Key result

Sodium hydroxyethylene diphosphonate reduces platelet deposition but not calcium content on bovine pericardial valves.

Why the study?

Does sodium hydroxyethylene diphosphonate reduce platelet deposition and calcification on bovine pericardial valves in calves?

Population

Healthy adult mongrel dogs and calves undergoing mitral valve replacement with a bovine pericardial valve

Comparison

Sodium hydroxyethylene diphosphonate (5 mg kg-1 day-1 s.c.) vs untreated in calves

Design

Animal experimental study

Follow-up

30 days

Authors

MDMrinal K. DewanjeeUniversity of Southern California PDPaul DidisheimNational Institutes of Health MKMichael P. KayeUniversity of Michigan

Discussion

Member takes

Implication

Diphosphonate may not prevent early bioprosthetic calcification despite reducing platelet deposition; leaves open platelet-independent mineralization pathways.

Key Points

To quantify temporal and regional patterns of platelet deposition and calcification on bovine pericardial mitral valve prostheses in animal models.
Implanted bovine pericardial mitral valves in dogs (assessed at 1, 14, and 30 days) and calves (assessed at 30 days) using autologous 111In-labeled platelets to monitor adhesion.
Evaluated regional valve deposition, the impact of sodium hydroxyethylene diphosphonate (5 mg/kg/day s.c.) in calves, and the effect of surface roughness using in vitro flow chambers.
Platelet radioactivity peaked at day 1 post-implantation, with sewing ring activity exceeding leaflet activity by 3- to 4-fold at day 1 before dropping to approximately half of leaflet levels by days 14 and 30.
Leaflet platelet accumulation in calves was highest at the free edge, followed by the central zone and flexion point; diphosphonate treatment reduced platelet deposition but did not decrease valve calcium content at 30 days.
In flow chamber tests, platelet deposition from heparinized blood was significantly lower on the smooth inner surface than on the rough outer surface of fixed pericardium.

Structured PICO

Does sodium hydroxyethylene diphosphonate reduce platelet deposition and calcification on bovine pericardial valves in calves?

Population

Healthy adult mongrel dogs and calves undergoing mitral valve replacement with bovine pericardial valves, evaluated at 1, 14, and 30 days post-implantation.

Intervention

Sodium hydroxyethylene diphosphonate (5 mg kg-1 day-1 s.c.) in calves

Comparator

Untreated calves

Outcome

Platelet deposition and calcium content on the valves at 30 dayssurrogate

Sodium hydroxyethylene diphosphonate reduces platelet deposition but not calcification on bovine pericardial valves in a calf model at 30 days.

Cite This Study

Dewanjee et al. (1984) studied Mitral valve replacement. Sodium hydroxyethylene diphosphonate vs. Untreated calves was evaluated on Platelet deposition and calcium content on the valves. Sodium hydroxyethylene diphosphonate reduced platelet deposition but did not reduce calcium content on bovine pericardial valves at 30 days compared with untreated calves.

synapsesocial.com/papers/6a998fda3c1419f58b4789f2 https://doi.org/10.1093/eurheartj/5.suppl_d.1

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Implication

Diphosphonate may not prevent early bioprosthetic calcification despite reducing platelet deposition; leaves open platelet-independent mineralization pathways.

Platelet deposition on and calcification of bovine pericardial valve

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Platelet deposition on and calcification of bovine pericardial valve

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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