Key result
Scanning electron microscopy of mechanical heart valves implanted in sheep without anticoagulation revealed early post-operative platelet deposition and aggregation, particularly near pivots.
Population
Sheep model with St. Jude Medical mechanical heart valves implanted in the mitral position
Design
Preclinical
Follow-up
2, 4, and 6 weeks
Authors
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Early platelet deposition on sheep valves without anticoagulation is hypothesis-generating; does not support changing human antiplatelet protocols.
Early post-operative platelet deposition occurs on mechanical heart valves in a sheep model without anticoagulation, supporting the recommendation for early antiplatelet therapy.
Okazaki et al. (1996) studied Mechanical heart valve implantation. St. Jude Medical mechanical heart valves without anticoagulants or antiplatelet agents was evaluated on Platelet deposition and morphologic changes on the pyrolytic carbon surface. Scanning electron microscopy of mechanical heart valves implanted in sheep without anticoagulation revealed early post-operative platelet deposition and aggregation, particularly near pivots.
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