Key result
A new Quatromer trileaflet polymeric heart valve induced similar platelet activation compared to St. Jude mechanical and tissue valves, with no significant difference observed.
Why the study?
Does a Quatromer trileaflet polymeric heart valve have comparable flow-induced platelet activation compared to standard mechanical and tissue valves in an in vitro model?
Population
In vitro model testing heart valves mounted in a left ventricular assist device
Comparison
Quatromer trileaflet polymeric heart valve vs St. Jude Medical bileaflet mechanical heart…
Design
Preclinical
Authors
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Quatromer valve thrombogenicity needs in vivo confirmation; leaves open clinical translation pending durability trials.
Does a Quatromer trileaflet polymeric heart valve have comparable flow-induced platelet activation compared to standard mechanical and tissue valves in an in vitro model?
A novel Quatromer trileaflet polymeric heart valve showed comparable in vitro thrombogenic potential to established mechanical and tissue valves, suggesting promising hemocompatibility.
Yin et al. (2005) studied Prosthetic heart valves. Quatromer trileaflet polymeric heart valve vs. St. Jude Medical bileaflet mechanical heart valve and St. Jude porcine bioprosthetic tissue valve was evaluated on Platelet activation state (PAS). A new Quatromer trileaflet polymeric heart valve induced similar platelet activation compared to St. Jude mechanical and tissue valves, with no significant difference observed.
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