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April 28, 2006Journal of Biomedical Materials Research Part B Applied Biomaterials

A novel polymer for potential use in a trileaflet heart valve

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Population

In vitro models for testing polymer properties

Comparison

Quatromer (poly) with and without polypropylene… vs Polyurethane approved for cardiovascular…

Design

Preclinical

Authors

SGSiobhain L. GallocherAAAndres Felipe AguirreVKVladimir Kasyanov

Discussion

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Overview

Quatromer-PP composites merit further preclinical testing for synthetic valves; leaves open translation to human durability and hemocompatibility.

Structured PICO

P
Population
In vitro models for testing polymer properties
I
Intervention
Quatromer (poly(styrene-b-isobutylene-b-styrene)) with and without polypropylene (PP) fibers
C
Comparator
Polyurethane (PUR) approved for cardiovascular applications, glutaraldehyde-fixed porcine valve material, and positive/negative controls
O
Outcome
Hemocompatibility (platelet deposition) and mechanical durability (static tensile tests, dynamic tension-tension, and bending fatigue tests)surrogate

Quatromer, particularly when reinforced with polypropylene fibers, demonstrates promising mechanical durability and hemocompatibility for potential use in synthetic trileaflet heart valves.

Cite This Study

Gallocher et al. (2006) studied this question.

synapsesocial.com/papers/6a7184bbfebe604dd70a253ahttps://doi.org/10.1002/jbm.b.30546
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In Vitro Comparison of Velocity Profiles and Turbulent Shear Distal to Polyurethane Trileaflet and Pericardial Prosthetic Valves1989 · 27 citations
  2. 2Vortex Shedding as a Mechanism for Free Emboli Formation in Mechanical Heart Valves1999 · 165 citations
  3. 3Heart valves: which is the best choice?1999 · 41 citations
  4. 4Platelet Adhesion to Simulated Stented Surfaces2003 · 28 citations
  5. 5Biodegradation of polyurethane under fatigue loading2003 · 34 citations