Why the study?
Valvular disease commonly requires mechanical prosthesis, driving the need for valve designs with biomaterials and coatings that improve hemocompatibility, reduce tissue ingrowth, and limit thrombotic effects.
Does Pyrolytic Carbon coating improve the surface topography and hemocompatibility of a graphite bileaflet mechanical mitral heart valve prototype?
Population
3D-CAD model prototype of a Bileaflet Mechanical Mitral Heart Valve fabricated from graphite
Comparison
Pyrolytic Carbon coating via Chemical Vapor Deposition vs uncoated graphite model
Design
In vitro preclinical material characterization and hemocompatibility study
Authors
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PyC-coated valve prototypes warrant in-vivo testing; leaves open clinical translation of improved in-vitro hemocompatibility.
Does Pyrolytic Carbon coating improve the surface topography and hemocompatibility of a graphite bileaflet mechanical mitral heart valve prototype?
A newly designed PyC-coated graphite bileaflet mechanical mitral heart valve prototype demonstrates smooth surface characteristics and excellent in-vitro hemocompatibility without hemolysis.
Mukhtiar et al. (2021) studied this question.
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