Key result
Chronic obstructive pulmonary disease significantly increased the risk of long-term all-cause mortality by 53% (HR 1.53) following coronary artery bypass grafting, independent of smoking status.
Why the study?
Chronic obstructive pulmonary disease is a common condition complicating major surgeries like CABG, and this study aimed to evaluate its impact on CABG outcomes.
Does COPD increase the risk of short-term and long-term mortality and MACCE in patients undergoing CABG?
Cohort (n=17,315)
No
Does COPD increase the risk of short-term and long-term mortality and MACCE in patients undergoing CABG?
Hazard Ratio: 1.53 (95% CI 1.31–1.79)
p-value: p=<0.001
COPD is a significant independent predictor of long-term mortality and MACCE following CABG, highlighting the need for optimized perioperative management in this high-risk population.
May inform post-CABG risk stratification and surveillance intensity; leaves open whether COPD-targeted interventions improve survival.
Chronic obstructive pulmonary disease (COPD) is a common condition that complicates major surgeries like coronary artery bypass grafting (CABG). This study aims to evaluate the impact of COPD on the outcome of CABG. A registry-based retrospective cohort study included individuals who received CABG between 2009 and 2016. Data were collected on patient demographics, intraoperative factors, and postoperative outcomes. Cox proportional hazard with inverse probability weighting (IPW) and propensity score matching (PSM) were conducted to assess the adjusted effect of COPD on 30-day and long-term mortality and major adverse cardiac and cerebrovascular events (MACCE). Moreover, the impact of COPD in smokers and non-smokers on short/long-term outcomes was assessed. Sensitivity analysis was conducted using multiple imputations. In the present investigation, 17,315 patients including 629 with COPD (mean age 69 ± 9.74), were followed up for a median duration of 8.25 years. Although COPD did not increase 30-day mortality and MACCE risk, the models showed that patients with COPD are at a significantly higher risk of long-term mortality and MACCE after CABG (IPW: HR for mortality: 1.53, 95% CI: 1.31-1.79; HR for MACCE: 1.29, 95% CI: 1.12-1.47). After multiple imputations, the mortality and MACCE hazard ratio in IPW analysis remained statistically significant. COPD significantly increases long-term mortality and MACCE following CABG, independent of smoking status.
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Najafi et al. (2025) conducted a cohort in Coronary artery disease requiring CABG (n=17,315). Chronic obstructive pulmonary disease (COPD) vs. Patients without COPD was evaluated on Long-term all-cause mortality (HR 1.53, 95% CI 1.31-1.79, p=<0.001). Chronic obstructive pulmonary disease significantly increased the risk of long-term all-cause mortality by 53% (HR 1.53) following coronary artery bypass grafting, independent of smoking status.
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