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Localization of αfp independent of the presence of serum was demonstrated only in a limited number of tumour cells in αfp‐positive hepatocellular carcinomas. These cells usually formed three‐dimensional groups with a definite tendency to localize near blood vessels and capillaries. Haematoxylin‐eosin staining did not reveal any morphological difference between αfp‐positive and ‐negative tumour cells.
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Goussev et al. (1971) studied this question.
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