Key result
Caspase inhibition with zVAD.fmk normalized endotoxin-induced reductions in fractional cell shortening and protected against sarcoplasmic reticulum calcium uptake capacity reduction.
Why the study?
Does caspase inhibition with zVAD.fmk prevent endotoxin-induced cardiomyocyte contractile dysfunction and calcium mishandling in adult male Sprague-Dawley rats?
RCT
Does caspase inhibition with zVAD.fmk prevent endotoxin-induced cardiomyocyte contractile dysfunction and calcium mishandling in adult male Sprague-Dawley rats?
Caspase inhibition protects against endotoxin-induced cardiomyocyte contractile dysfunction by preventing sarcoplasmic reticulum calcium uptake reduction and mitochondrial dysfunction.
Caspase inhibition may preserve cardiomyocyte function in rat endotoxemia; leaves open translation to human sepsis.
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Nevière et al. (2010) conducted an RCT in Endotoxin-induced cardiomyocyte contractile dysfunction. zVAD.fmk vs. Endotoxin alone was evaluated on Contractile parameters and cellular calcium homeostasis. Caspase inhibition with zVAD.fmk normalized endotoxin-induced reductions in fractional cell shortening and protected against sarcoplasmic reticulum calcium uptake capacity reduction.
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