Key result
Insulin (100 ng/mL) and IGF-I significantly reduced IGFBP-1 production in human granulosa cells compared to controls (1.6 and 0.3 ng/mL vs 7.0 ng/mL; P<0.01).
Population
Human granulosa cells obtained during in vitro fertilization, plated at 10(5) cells/0.5 mL.
Comparison
Insulin or IGF-I added with or without 2 h… vs Control cells.
Design
Preclinical
Follow-up
48 hours
Authors
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May modulate ovarian IGFBP-1 via distinct receptors; leaves open relevance to fertility in hyperinsulinemic states.
Absolute Event Rate: 1.6% vs 7%
p-value: p=<0.01
In human granulosa cells, both insulin and IGF-I inhibit IGFBP-1 production, but insulin exerts its effect via the insulin receptor while IGF-I acts via a different receptor.
Poretsky et al. (1996) studied In vitro human granulosa cells. Insulin and IGF-I vs. Control cells was evaluated on IGFBP-1 culture medium concentration (p=<0.01). Insulin (100 ng/mL) and IGF-I significantly reduced IGFBP-1 production in human granulosa cells compared to controls (1.6 and 0.3 ng/mL vs 7.0 ng/mL; P<0.01).
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