A comparison of three 7-day triple regimens in the eradication of Helicobacter pylori infection. Preliminary results

The aim of this study is to investigate the change of the severity of intestinal metaplasia (IM) in the antral and body mucosa after Helicobacter pylori eradication. Methods: The subjects included 15 patients who achieved H. pylori eradication (8 with atrophic gastritis, 5 with duodenal ulcers, and 2 with gastric ulcers, 6 males, mean age 51 yr). All patients underwent endoscopy, and biopsies were taken from the lesser and greater curvatures of the midantrum and middle body, and the lesser curvature of the incisura angularis of the stomach. The state of 1-1. pylori infection was assessed histologically (Giemsa stain). Histological severity of IM was graded as "no," "mild," "moderate," and "marked," according to the Updated Sydney System, and scored on a 0-3 scale (using hematoxylin and eosin, Alcian blue/periodic acid Schiff, and high iron diamine/Alcian blue stains). The patients were followed for 12-33 (mean 18) months after anti-/-/, pylori therapy. The IM scores were compared between before and after eradication (at the end of follow-up), using one sample Wilcoxon test. Results: The IM scores before and after eradication were shown: