Key result
An impedance aggregometry method was successfully developed and validated to measure the additive effect of serotonin on collagen-induced platelet aggregation in human whole blood.
Answers are grounded in this paper and cite their sources.
A new validated impedance aggregometry method allows for the measurement of serotonin-induced platelet aggregation in whole blood, facilitating the evaluation of novel antiplatelet agents.
Upon erosion and rupture of an atherosclerotic plaque, collagen and serotonin (5-hydroxytyramine [5-HT]) induce a process of simultaneous platelet aggregation and vasoconstriction. Simultaneous inhibition of these pathophysiological processes, attainable by 5-HT inhibition, is a potential drug target and could offer an attractive treatment modality. The availability of a reliable and accurate test to measure inhibition of 5-HT-induced platelet aggregation would facilitate the rational development of such new compounds. Therefore, we developed a validated method to measure the additive effect of 5-HT on platelet aggregation in human whole blood after an initial induction by a low-concentration collagen, using impedance aggregometry. This method is feasible to measure 5-HT-induced platelet aggregation in whole blood for the evaluation of promising platelet aggregation inhibitors possessing 5-HT antagonistic activity. The availability of this method will support and stimulate selective 5-HT antagonism as effective management of thrombosis.
No takes yet. Share an insight, caveat, or question.
Moerland et al. (2010) studied Thrombosis. Impedance aggregometry method was evaluated on Measurement of the additive effect of 5-HT on platelet aggregation in human whole blood. An impedance aggregometry method was successfully developed and validated to measure the additive effect of serotonin on collagen-induced platelet aggregation in human whole blood.
Synapse has enriched 10 related papers. Consider them for comparative context: