Key result
Serotonin does not activate platelets per se, but dose-dependently enhances platelet activation induced by ADP and thrombin in whole blood, increasing ADP-induced fibrinogen binding by up to 79%.
Population
Whole blood samples (n=9 to 12)
Comparison
Serotonin at concentrations up to 10 mol/l… vs Samples without 5-HT or treated with 5-HT2A…
Design
Preclinical
Authors
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5-HT alone fails to aggregate platelets in whole blood; leaves open its potentiating role and requires in vivo validation before clinical consideration.
p-value: p=<0.05
Serotonin acts as a helper agonist in whole blood, dose-dependently enhancing platelet activation induced by ADP and thrombin via 5-HT2A receptors.
Li et al. (1997) studied this question. Serotonin (5-HT) was evaluated on Platelet activation (fibrinogen binding, P-selectin expression, and aggregation) (p=<0.05). Serotonin does not activate platelets per se, but dose-dependently enhances platelet activation induced by ADP and thrombin in whole blood, increasing ADP-induced fibrinogen binding by up to 79%.
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