Key result
Serotonin enhanced platelet aggregation to tissue factor-rich microvesicles compared to microvesicles alone (maximum peak 55.9% vs 48.7%, P<0.05).
Why the study?
Does serotonin enhance the interaction of human platelets with tissue factor-rich microvesicles and increase their procoagulant activity?
Population
Human platelets (heparinized platelet-rich plasma and washed platelets)
Comparison
Serotonin addition to tissue factor-rich… vs TF-MVs alone
Design
Preclinical
Authors
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Should not change practice; hypothesis-generating for serotonin's role in human thrombosis.
Does serotonin enhance the interaction of human platelets with tissue factor-rich microvesicles and increase their procoagulant activity?
Absolute Event Rate: 55.9% vs 48.7%
p-value: p=<0.05
Serotonin enhances the interaction of platelets with tissue factor-rich microvesicles, increasing platelet activation and procoagulant activity, which may have implications for thrombus formation in high cardiovascular risk states.
López-Vílchez et al. (2009) studied this question. Serotonin vs. Tissue factor-rich microvesicles (TF-MVs) alone was evaluated on Platelet aggregation to TF-MVs (maximum peak) (p=<0.05). Serotonin enhanced platelet aggregation to tissue factor-rich microvesicles compared to microvesicles alone (maximum peak 55.9% vs 48.7%, P<0.05).
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