Key result
Serotonin significantly increased tissue factor and PAI-1 mRNA expression in a concentration- and time-dependent manner in cultured rat aortic endothelial cells.
Why the study?
Does serotonin induce the expression of coagulative and fibrinolytic factors in cultured rat aortic endothelial cells?
Population
Cultured rat aortic endothelial cells
Comparison
Serotonin at various concentrations vs Unstimulated cells (implied)
Design
Preclinical
Authors
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May link platelet serotonin to endothelial procoagulant shift; leaves open in vivo relevance and clinical translation.
Does serotonin induce the expression of coagulative and fibrinolytic factors in cultured rat aortic endothelial cells?
Serotonin promotes procoagulant and hypofibrinolytic activities in endothelial cells via the 5-HT2A receptor, providing a mechanistic link to thrombus formation at sites of vessel injury.
Kawano et al. (2001) studied this question. Serotonin (5-HT) vs. Unstimulated cells / 5-HT receptor antagonists was evaluated on Expressions of tissue factor (TF), tissue factor pathway inhibitor (TFPI), plasminogen activator inhibitor-1 (PAI-1), and tissue-type plasminogen activator (TPA) mRNAs. Serotonin significantly increased tissue factor and PAI-1 mRNA expression in a concentration- and time-dependent manner in cultured rat aortic endothelial cells.
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