What question did this study set out to answer?

To evaluate whether patients with major depressive disorder show functional abnormalities in the platelet 5-HT2A receptor pathway.

August 22, 2002Human Psychopharmacology Clinical and Experimental

Platelet 5‐HT2A‐receptor‐mediated induction of aggregation is not altered in major depression

View Full Paper

Ask AI

Bookmark

Why the study?

Is the functional status of the platelet 5-HT2A receptor pathway altered in patients with major depression compared to controls?

Population

45 individuals, comprising 30 untreated patients with major depressive disorder and 15 controls.

Comparison

Measurement of serotonin-amplified platelet… vs Healthy controls

Design

Case-control

Authors

EGEsther Gómez‐GilNeurosciences Institute CGCristòbal GastóHospital Clínic de Barcelona MDMaribel Díaz‐RicartConsorci Institut D'Investigacions Biomediques August Pi I Sunyer

Discussion

Member takes

Implication

No evidence of altered platelet 5-HT2A function in depression by aggregation assay; leaves open alternative mechanisms for depression-thrombosis associations.

Key Points

To evaluate whether patients with major depressive disorder show functional abnormalities in the platelet 5-HT2A receptor pathway.
Measured the percentage of serotonin-amplified platelet aggregation in response to adenosine diphosphate (ADP) in 30 untreated patients with major depressive disorder and 15 healthy controls.
Assessed depression severity among patients using the Hamilton Depression Rating Scale.
No statistically significant difference in serotonin-amplified platelet aggregation was observed between untreated depressed patients and healthy controls.
No correlation emerged between the magnitude of platelet aggregation response and the severity of depression measured by the Hamilton scale.

Structured PICO

Is the functional status of the platelet 5-HT2A receptor pathway altered in patients with major depression compared to controls?

Population

45 individuals, comprising 30 untreated patients with major depressive disorder and 15 controls.

Intervention

Measurement of serotonin-amplified platelet aggregation to adenosine diphosphate (ADP)

Comparator

Healthy controls

Outcome

Percentage of serotonin-amplified platelet aggregation to ADPsurrogate

The functional status of platelet 5-HT2A receptors, as measured by serotonin-amplified platelet aggregation, is not altered in major depression.

Cite This Study

Gómez‐Gil et al. (2002) studied this question.

synapsesocial.com/papers/6a836db5b89212e03e9eedda https://doi.org/10.1002/hup.429

View Full Paper

Ask AI

Bookmark

Implication

No evidence of altered platelet 5-HT2A function in depression by aggregation assay; leaves open alternative mechanisms for depression-thrombosis associations.

Platelet 5‐HT2A‐receptor‐mediated induction of aggregation is not altered in major depression

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Platelet 5‐HT2A‐receptor‐mediated induction of aggregation is not altered in major depression

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider