Experimental study demonstrates ruthenium-catalyzed [3+2] annulation of 2-arylcyclo-2-enones with alkynes, highlighting an atom-economical route to complex spiro carbocyclic indenes.
An air-stable half-sandwich ruthenium(II) complex, [Ru(p-cymene)(MeCN)3](SbF6)2, was synthesized and characterized. It exhibited unique catalytic ability in a [3+2] annulation reaction of 2-arylcyclo-2-enones with internal alkynes via C(sp(2))-H/alkene functionalization, which offered a rapid and atom-economical methodology to construct various synthetically challenging spiro carbocyclic indenes bearing a quaternary carbon.
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Zhao et al. (2016) studied this question.
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