Why the study?
Does intravenous methylprednisolone pulse therapy increase the risk of complex ventricular arrhythmias in patients with nephrotic syndrome?
Population
25 patients with nephrotic syndrome
Comparison
Intravenous methylprednisolone pulse therapy vs Control period (baseline before therapy)
Design
Cohort
Follow-up
During the course of therapy
Authors
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Methylprednisolone pulses may be linked to complex ventricular arrhythmias in nephrotic syndrome; leaves open causal confirmation in randomized trials.
Does intravenous methylprednisolone pulse therapy increase the risk of complex ventricular arrhythmias in patients with nephrotic syndrome?
Intravenous methylprednisolone pulse therapy in nephrotic syndrome patients may be associated with complex ventricular arrhythmias, potentially related to abrupt changes in potassium metabolism.
Fujimoto et al. (2008) studied this question.
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