Key result
Methylprednisolone pulse therapy linked to transient renal failure in ~20% of patients with prior renal impairment.
Why the study?
The effect of methylprednisolone pulse therapy on renal function in patients with renal or collagen disease was examined due to concerns about transient renal failure.
Does methylprednisolone pulse therapy affect renal function in patients with renal or collagen disease?
Population
15 patients with renal or collagen disease
Comparison
Renal function before and after methylprednisolone pulse therapy
Design
Observational case series
Authors
Loading...
MP pulse therapy warrants caution in nephrotic patients with reduced function; Level 5 data leaves open causality and need for prospective trials.
Observational (n=15)
Does methylprednisolone pulse therapy affect renal function in patients with renal or collagen disease?
Methylprednisolone pulse therapy may induce transient renal failure in patients with nephrotic syndrome and pre-existing renal impairment, possibly due to sodium and water retention.
Sakemi et al. (1991) conducted an observational in Renal or collagen disease (n=15). Methylprednisolone pulse therapy was evaluated on Renal function (changes in serum creatinine, body weight, and urine volume). Methylprednisolone pulse therapy induced transient renal failure in 3 of 15 patients, specifically those with prior reduced renal function and active renal disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: