Key result
Intravenous infusion of isoprenaline caused a statistically significant decrease in the peripheral platelet count in healthy male volunteers, with no dose-response curve observed.
Why the study?
Does intravenous infusion of isoprenaline affect peripheral platelet count in healthy male volunteers?
Does intravenous infusion of isoprenaline affect peripheral platelet count in healthy male volunteers?
Intravenous isoprenaline significantly decreases peripheral platelet count in healthy volunteers, potentially by sequestering platelets in the spleen.
Answers are grounded in this paper and cite their sources.
Isoprenaline may sequester platelets in healthy subjects; leaves open clinical relevance, monitoring needs, and effects in patients.
5 healthy male volunteers received i.v. infusions of isoprenaline in doses of 0.03, 0.06 and 0.09 mug X kg-1 X min-1 over a period of 6 min. A statistically significant decrease in the peripheral platelet count was obtained, but no dose-response-curve for isoprenaline was observed. It is suggested that while an i.v. infusion of epinephrine causes a release of platelets from the exchangeable splenic platelet pool, isoprenaline might have the opposite effect on the spleen, thereby causing a decrease of platelets in the peripheral blood.
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OLSSON et al. (1976) studied Healthy (n=5). Isoprenaline was evaluated on Peripheral platelet count. Intravenous infusion of isoprenaline caused a statistically significant decrease in the peripheral platelet count in healthy male volunteers, with no dose-response curve observed.
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