Key result
Takotsubo cardiomyopathy was associated with a blunted cortisol stress response compared to healthy controls (median difference -3.2 nmol/L, p=0.022), but not compared to NSTEMI patients.
Why the study?
Do female patients with takotsubo cardiomyopathy exhibit altered cortisol awakening and stress responses compared to NSTEMI patients and healthy controls?
Population
59 women, comprising 19 female patients with takotsubo cardiomyopathy, 20 female patients with…
Design
Case-control
Authors
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Does not distinguish Takotsubo from NSTEMI by cortisol response; hypothesis-generating for stress-related mechanisms, no practice change warranted.
Case-Control (n=59)
Do female patients with takotsubo cardiomyopathy exhibit altered cortisol awakening and stress responses compared to NSTEMI patients and healthy controls?
Effect estimate: Median difference -3.2 nmol/L
p-value: p=0.022
Takotsubo cardiomyopathy is associated with a blunted cortisol stress response and a higher incidence of stressful life events compared to healthy controls, suggesting a potential role of chronic stress in its pathogenesis.
Kastaun et al. (2014) conducted a case-control in Takotsubo cardiomyopathy (n=59). Takotsubo cardiomyopathy vs. NSTEMI patients and healthy controls was evaluated on Cortisol stress response (CSR) (Median difference -3.2 nmol/L, p=0.022). Takotsubo cardiomyopathy was associated with a blunted cortisol stress response compared to healthy controls (median difference -3.2 nmol/L, p=0.022), but not compared to NSTEMI patients.
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