Key result
Hybrid heart valve scaffolds enhanced with bioresorbable polymers demonstrated feasibility and improved biomechanical function for application in tissue engineering.
A novel hybrid heart valve scaffold enhanced with bioresorbable polymers demonstrates improved biomechanical function, suggesting feasibility for tissue engineering applications.
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Advances preclinical hybrid valve engineering; leaves open human translation pending further studies.
Hybrid heart valve scaffolds were fabricated from decellularized porcine aortic heart valve matrices and enhanced with bioresorbable polymers using different protocols: (i) dip coating of lyophilized decellularized matrices, and (ii) impregnation of wet decellularized matrices. The following polymers were evaluated: poly(4-hydroxybutyrate) and poly(3-hydroxybutyrate-co4-hydroxybutyrate). Tensile tests were conducted to assess the biomechanical behavior of valve leaflet strips. Suture retention strength was evaluated for the adjacent conduit. A pulse duplicator system was used for functional testing of the valves under physiological systemic load conditions. The properties of the hybrid structures were compared with native, decellularized, and glutaraldehyde-fixed specimens. Mechanisms of the polymer impregnation process were studied with IR spectroscopy, fluorescent microscopic imaging, and SEM. Altogether this study demonstrates the feasibility and improved biomechanical function of a novel hybrid heart valve scaffold for an application in tissue engineering.
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Grabow et al. (2004) studied Tissue engineering of heart valves. Hybrid heart valve scaffolds enhanced with bioresorbable polymers vs. Native, decellularized, and glutaraldehyde-fixed specimens was evaluated on Biomechanical behavior, suture retention strength, and functional testing. Hybrid heart valve scaffolds enhanced with bioresorbable polymers demonstrated feasibility and improved biomechanical function for application in tissue engineering.
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