VOSS AND LOEWE [1931] and Moore and Gallagher [1930] have described certain restoration phenomena in secondary sex organs of castrated mice and rats respectively, by treatment with male hormone, the former authors being the first to use changes in the epithelium of the seminal vesicles as a rapid cytological test for the action of the hormone. Complete restoration was claimed by Moore and Gallagher [1930] to result from administration of 5 capon units (as-defined by Gallagher and Koch [1930]) daily for 21 days, this daily dose being equivalent to 7-5 capon units as defined by Freud et al. [1932].
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John Freud (1933) studied this question.
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