Key result
Adenovirus-mediated SDF-1 gene transfer improved cardiac structure and function after myocardial infarction through angiogenesis and anti-apoptosis compared to control or Adv-LacZ.
Why the study?
Does AdV-SDF-1 gene transfer improve cardiac structure and function after myocardial infarction in a preclinical model?
Does AdV-SDF-1 gene transfer improve cardiac structure and function after myocardial infarction in a preclinical model?
Adenovirus-mediated SDF-1 gene transfer improves cardiac structure and function post-myocardial infarction via angiogenesis and anti-apoptosis in a preclinical model.
Supports SDF-1 gene therapy exploration post-MI in models; leaves open clinical translation and safety trials.
In our study, we found cardiocytes expressed CXCR4, and the number of cardiocytes apoptosis with SDF-1 treatment decreased obviously through SDF-1 induced the up-regulation of phosphorylated Akt. On day 7 after myocardial infarction, marked expression of SDF-1alpha, and the number of CD133(+) cells was the highest in the AdV-SDF-1 injection hearts. On day 28 post-treatment, blood vessel density in the AdV. SDF-1 group was higher in infracted zones. Infarct size and collagen accumulation in the infracted area decreased significantly, thickness of LV wall, vessels and cardiocytes' density increased obviously in the AdV-SDF-1 group than in control or Adv-LacZ group, and hemodynamics showed the improvement of left ventricle heart function in the AdV.SDF-1 group. Therefore, SDF-1alpha could improve cardiac structure and function through the combined effects of angiogenesis and anti-apoptosis.
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Tang et al. (2008) studied Myocardial infarction. Adenovirus-mediated stromal cell-derived-factor-1 (AdV-SDF-1) gene transfer vs. Control or Adv-LacZ group was evaluated on Cardiac structure and function (infarct size, collagen accumulation, blood vessel density, hemodynamics). Adenovirus-mediated SDF-1 gene transfer improved cardiac structure and function after myocardial infarction through angiogenesis and anti-apoptosis compared to control or Adv-LacZ.
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