Key result
Introduction of a pentavalent rotavirus vaccine was associated with an 87% reduction in community-acquired rotavirus gastroenteritis cases compared to the 2005-2006 season.
Why the study?
Does the introduction of a pentavalent rotavirus vaccine reduce cases of rotavirus gastroenteritis in children?
Population
Children presenting to The Children's Hospital of Philadelphia with acute gastroenteritis
Comparison
Introduction of pentavalent rotavirus vaccine vs Historical periods before vaccine introduction
Design
Cohort
Authors
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May inform pediatric vaccination strategies; observational data leaves open questions on causality and generalizability.
Observational
No
Does the introduction of a pentavalent rotavirus vaccine reduce cases of rotavirus gastroenteritis in children?
Effect estimate: 87% reduction
The introduction of the pentavalent rotavirus vaccine was associated with an 87% reduction in community-acquired rotavirus gastroenteritis cases at a major pediatric hospital.
Clark et al. (2009) conducted an observational in Rotavirus gastroenteritis. Pentavalent rotavirus vaccine vs. Historical pre-vaccine period (2005-2006) was evaluated on Community-acquired cases of rotavirus gastroenteritis (87% reduction). Introduction of a pentavalent rotavirus vaccine was associated with an 87% reduction in community-acquired rotavirus gastroenteritis cases compared to the 2005-2006 season.
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