April 21, 2004Cardiovascular Research

Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-β1 involves furin-convertase

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Population

Cardiac fibroblasts (CFBs) from adult Sprague-Dawley rats

Design

Preclinical

Authors

PSPhilipp StawowyHumboldt-Universität zu Berlin CMChristian MargetaVienna General Hospital HKHeike KallischDeutsches Herzzentrum der Charité

Discussion

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Implication

Furin inhibition merits further study in cardiac fibrosis models; leaves open translation to human remodeling therapies.

Structured PICO

Population

Cardiac fibroblasts (CFBs) from adult Sprague-Dawley rats

Intervention

Stimulation with TGF-beta1 (20 ng/ml) and/or inhibition of furin

Outcome

MMP-activity (MT1-MMP/MMP-2) and cell motility/migrationsurrogate

TGF-beta1 induces MMP activity and motility in cardiac fibroblasts via the convertase furin, suggesting furin as a potential therapeutic target in cardiac remodeling and fibrosis.

Cite This Study

Stawowy et al. (2004) studied this question.

synapsesocial.com/papers/6a99b705bda18ee3fd844f25 https://doi.org/10.1016/j.cardiores.2004.03.010

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Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-β1 involves furin-convertase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-β1 involves furin-convertase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider